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Clinical Validation
& Research

Backed by 4+ years of research and clinical validation

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~ 85-90% Sensitivity
~ 75-80% Specificity

Flagged ischemic changes
from both obstructive
and non-obstructive CAD

Performed better than
traditional treadmill
ECG tests in patients
from both wellness and
perfusion testing labs

PulzCAD™ isn't just a better tool — it's a clinically validated breakthrough in cardiac diagnostics.

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Research History

20+ Years of medical research on stress ECG analysis has identified numerous new ECG features to explore beyond ST segment depression

clinical validation
clinical validation
clinical validation
clinical validation
clinical validation
clinical validation

QRS segment features such as high frequency components, QRS score, etc.

ST segment features such as recovery phase and slope characteristics

T-wave features such as rise/fall slope locations and ratios, QT distance, etc.

Study Design

How We Tested PulzCAD™

Research & Development
(300+ Patients)

R&D

PulzCAD™ was used alongside traditional treadmill tests on patients already undergoing nuclear stress tests, catheter coronary angiogram, or cardiac CT angiograms scans.

Blind Validation
(250+ Patients)

Validation

PulzCAD™ results were analyzed without knowledge of CT/angiogram outcomes to assess objective performance.

Data from Two Cohorts

Wellness Clinic

Routine checks using traditional Stress ECG and Cardiac CT Angiogram

Nuclear Perfusion Testing Lab

With known/suspected CAD using nuclear stress test or angiogram

Final analysis performed on 190+ patient samples after quality screening.

Results At a Glance

Patient Group
Reference Test
Sensitivity
Specificity
Nuclear Stress Perfusion Lab
Coronary Angiogram
90%
88%
Wellness Lab
Cardiac CT Angiogram
86%
78*%
i mark

* Beyond Obstructive CAD: PulzCAD also flagged non-obstructive cardiac abnormalities that could be causing ischemic conditions at higher heart rates such as myocardial bridging, Type III LAD, small and diffuse vessels, HCM, etc.

Why This Matters

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Earlier Detection

PulzCAD picks up critical ECG changes during stress — before symptoms become severe.

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Scientifically Explainable

Backed by peer-reviewed methods and medically interpretable ECG features.

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Reduced Misdiagnosis

Fewer false positives/negatives compared to outdated treadmill ECG methods.

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Faster, More Accurate, More Scalable

Test, process, and generate scores — all within ~5 minutes of completing the stress test.

Ongoing Research & Future Applications

PulzCAD shows promise not just for diagnosing obstructive CAD, but also for non-obstructive CAD and other complex cardiac conditions. Further studies are underway to explore its use across: